RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
LCN2
RNA ID
RNA Type
mRNA
Alteration Pattern
up regulation
Species
homo sapiens
Detection Methods
Cell Culture; Microarray Statistical Data Analysis; Gene Expression Analysis
Target
NA
Pathway
NA
PubMed ID
Title
A novel genomic signature with translational significance for human idiopathic pulmonary fibrosis
Year
2015
Function
"Remarkably, similar expression change intensities were found for several common differentially expressed genes in both species (Figure 2, Tables 2 and and3),3), such as matrix metallopeptidase 7 (MMP7/Mmp7; 9.2-fold in IPF, 21.1-fold in bleomycin), the phospholipase A2, group 2A (PLA2G2A/Pla2 g2a; 7.8-fold in IPF, 4.3-fold in bleomycin), lipocalin-2 (LCN2/Lcn2 4.6-fold in IPF, 3.5-fold in bleomycin), collagen triple helix repeat containing 1 (CTHRC1/Cthrc1; 4.3-fold in IPF, 3.2-fold in bleomycin), and complement component 6 (C6; 3.7-fold in IPF, 6.5-fold in bleomycin)."